Cincinnati Reds vs St. Louis Cardinals Prediction (July 24): Odds, Pick & Analysis

Cincinnati Reds vs St. Louis Cardinals · July 24, 2026 · 8:15 PM EDT · Photo: ESPN
The Cincinnati Reds arrive in St. Louis with an offensive profile that ranks among baseball's weakest, while the Cardinals have built a more balanced attack that should prove decisive in this National League Central matchup. Cincinnati's .230 batting average and .709 OPS stand in stark contrast to St. Louis's .241 average and .701 OPS—a modest gap that masks a deeper talent disparity when examining the quality of each lineup's core contributors.
Tonight's Odds
Probable Pitchers
Cincinnati Reds
RHP Rhett Lowder
St. Louis Cardinals
RHP Dustin May
The Cardinals' offense centers on Jordan Walker, whose .291 batting average and .871 OPS represent the division's most dangerous individual threat at the plate. Walker has also driven in 22 home runs this season, anchoring an attack that has produced 4.45 runs per game. Alec Burleson provides secondary punch with a .284 average and .814 OPS, giving St. Louis two elite contributors in the middle of the order. The Cardinals' pitching staff, led by Michael McGreevy's 3.07 ERA, has allowed opponents to bat just .253, indicating strong defensive execution and quality pitch sequencing. The team's 4.18 ERA and 1.34 WHIP reflect a balanced rotation capable of suppressing runs across extended stretches.
Cincinnati's lineup, by contrast, leans heavily on Elly De La Cruz, whose .276 average and .854 OPS represent a bright spot in an otherwise anemic offensive environment. De La Cruz's 99 strikeouts highlight a concerning trend across the Reds' batting order—the team is striking out at a high rate while generating just 4.19 runs per game. Sal Stewart has contributed 21 home runs, but his .249 average and .799 OPS cannot offset the offensive deficiencies elsewhere. The Reds' pitching situation is further complicated by injuries to Nick Lodolo and Tony Santillan, both on the 15-day injured list. Rhett Lowder, Cincinnati's probable starter, carries a 5.75 ERA with a 3-7 record—statistics that suggest vulnerability against St. Louis's more disciplined hitters.
St. Louis's Dustin May presents a more formidable mound presence than Lowder, posting a 4.78 ERA with a 5-7 record. Though May has struggled with consistency, he operates within a superior pitching infrastructure that has kept the Cardinals competitive in a tight wild-card race. Cincinnati sits 6.0 games back in wild-card positioning with a 47-54 record, while St. Louis occupies 1.5 games back at 52-50. The Cardinals' recent form—though marked by a one-game losing streak—provides more stability than Cincinnati's underlying metrics suggest.
The Cardinals' balanced offensive attack, superior pitching depth, and healthier roster construction align with the -164 moneyline. St. Louis's ability to generate consistent run production through Walker and Burleson, paired with McGreevy's elite ERA anchoring the rotation, creates a structural advantage that should overcome May's recent inconsistency. Cincinnati's reliance on De La Cruz in an otherwise weak lineup, combined with starting pitcher deterioration and key injuries, positions the Reds as clear underdogs in this divisional contest.
Best Bet
St. Louis Cardinals (-164)
Based on the matchup analysis, recent form, and line value, St. Louis Cardinals (-164) is our top play for this game.

